The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: A Systematic Review and Meta-analysis of Randomized Controlled Trials

T2DM is an investigated prevailing endocrine disorder. In computation to CVDs, hypertension has been contemplated as the main risk factor for the development of T2DM. Therefore, blood pressure (BP) management could take the edge off of stroke and mortality, especially among patients with T2DM. Hence, natural supplements have been regarded prudent to normalize BP along with other beneficial effects. There are several studies indicating that magnesium (Mg) supplementation, as the fourth most abundant mineral in the body, might lower BP. Omid Asbaghi and colleagues carried out literature review titled “The Effects of Magnesium Supplementation on Blood Pressure and Obesity Measure Among Type 2 Diabetes Patient: A Systematic Review and Meta-analysis of Randomized Controlled Trials” published in Biological Trace Element Research Journal.

Objective:

To evaluate the effects of magnesium (Mg) supplementation on blood pressure (BP) and obesity measure among patients with type 2 diabetes mellitus (T2DM).

Method:

The current systematic review and meta-analysis were conducted based on the PRISMA guidelines. A comprehensive and systematic literature searches were carried out through the Web of Science, the Cochrane library, PubMed, and Scopus databases were rooted for data referencing and corresponding evaluation was drawn.

Finding:

The findings of the present meta-analysis showed an overall reduction in SBP and DBP by Mg supplementation among T2DM patients. The findings of the present study indicated that Mg supplementation for > 12 weeks or in doses higher than 300 mg/day could significantly improve the BP in type 2 diabetic subjects. It has been demonstrated that Mg could alter lipid profile of diabetic patients, improve IR and hyperglycemia, therefore improves the clinical conditions and reduce the hypertension and related organ damage. Lifestyle modifications such as adherence to DASH diet in concordance to Mg supplementation may further improve BP control in T2DM patients.

Limitation:

The baseline serum levels of Mg in most of RCTs comprehended in this study was not entailed. The final limitation was the evidence of heterogeneity across the studies, especially in their design and methodologies.

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