Perirenal Fat Thickness Is Significantly Associated with the Risk for Development of CKD in Patients with Diabetes
The burden of chronic kidney disease (CKD) in patients with diabetes is increasing. Obesity is an important risk factor for the development and progression of CKD in patients with diabetes. waist circumference (WC) and visceral adipose tissue (VAT), have been shown to be superior to BMI for predicting the development and progression of CKD in patients with diabetes. CKD not only is the major cause of end-stage kidney disease but also is associated with higher cardiovascular risk in people with diabetes. Xiangiun and colleague conducted a study under title “Perirenal fat thickness is significant associated with the risk for development of chronic kidney disease in patients with diabetes” in Diabetes Journal. The summary of this research is given below:
Objective:
To investigate whether perirenal fat is an independent predictor for chronic kidney disease (CKD) and compare it with total, subcutaneous, or visceral fat in patients with diabetes.
Method:
A total of 190 patients were included in the longitudinal study. Anthropometric measurements, including height, weight, WC, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were obtained from all participants. Hba1c, TC, HDL, TG, CRP was measured. Perirenal fat thickness was measured by a trained radiologist. Serum creatinine, uric acid, urinary creatinine, and albumin were measured with an automatic biochemical analyzer. eGFR was calculated
Findings:
Levels of BMI, WC, TBF, SAT, and VAT were elevated in subjects with higher PRFT, while eGFR was significantly decreased. The levels of BMI, WC, TBF, SAT, and VAT in the CKD group tended to be higher than those in the non-CKD group. Analysis showed that age, SBP, eGFR, insulin therapy, antihypertensive drugs, PRFT, and VAT were associated with increased risk of CKD. Perirenal fat could independently predict CKD incidence in patients with T2DM. More importantly, perirenal fat had a higher predictive value for CKD than total, subcutaneous, or visceral fat in T2DM patients. In conclusion, with perirenal fat, there was a higher predictive value for CKD than with total, subcutaneous, or visceral fat in T2DM.
Image Credit : Woman photo created by user18526052 – www.freepik.com
