Mortality risk remains higher in individuals with type 1 diabetes: A population-based cohort study (the Ayrshire diabetes follow-up cohort [ADOC])
Type 1 diabetes is known to increase the risk of cardiovascular disease and all-cause mortality. Previous studies have demonstrated that blood pressure control, treatment of dyslipidemia, and intensive glycaemic control along with cessation of smoking helps in improving diabetes. Andrew Collier MD and colleagues conducted research under the title “Mortality risk remains higher in individuals with type 1 diabetes: A population-based cohort study (the Ayrshire diabetes follow-up cohort [ADOC])” published in the Diabetes, Obesity and Metabolism Journal. The summary of this study is given below:
Objective:
To compare events of mortalities in individuals with type 1 diabetes as compared to non-diabetic individuals.
To evaluate the effects of age, gender, socio-economic status, glycaemic control, hypertension, smoking status, ischemic heart disease (IHD), body mass index (BMI), and dyslipidemia.
Method:
A population-based analysis was conducted in Ayrshire and Arran, Scotland including 253,304 non-diabetic individuals and 1324 type 1 diabetics who were tracked from 2009 to 2014.
Findings:
The study suggests that the risk of mortality is high in patients with type
1 diabetes as compared to the general population. Age, IHD, hypertension, smoking, and deprivation increases this risk. Individuals with diabetes, few without significant IHD, have an increased risk to undergo statin therapy, anti-hypertensive medication, particularly ACE inhibitors, and possibly aspirin therapy than their non-diabetic counterparts. Reports found an association of obesity with lower mortality.
Limitation:
Investigators didn’t analyze the effect of weight loss and weight gain during the study period. Data regarding the duration of diabetes and status of renal function is missing for the study population. The study subjects had varying degrees of onset before 2009. Lastly, there is a chance of decreased participants due to premature death.
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