Impact of age at T2DM diagnosis on mortality and vascular complications: systematic review and meta-analyses

T2DM equates with surged mortality and morbidity in contrast to the general population. Surprisingly, T2DM diagnosed at an early young stage is shown to be associated with greater risk of mortality and vascular disease. Hence Natalie Nanayakkara and colleagues extracted data and summarized article titled “Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyse”

Objective:

To imply interdependence of T2DM onset age and risk of related complications.

Methods:

MEDLINE and All EBM databases were rooted for data referencing and corresponding evaluation was carried out.

Finding:

The findings highlight the importance of cardiovascular risk management in diabetics. With increasing age development of macrovascular complications is more evident, hence it is vital to put out preventive measures to minimize highest short-term absolute risk. However, early T2DM diagnosis is prime in young population to reduce related drawbacks, and thus crucial to control blood glucose during their lifetime.
Diabetes Management Guidelines should highlight the variance of absolute and lifetime risks between younger and older population. Hence, promotion of screening programmes in older and preventive measures in younger population early detection of T2DM is put forward.

Limitations:

There are limitations in RCT studies on achieving good glycaemic control and hence may not reflect pathophysiology of T2DM in younger population.

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