Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients
SARS-CoV2 has affected 25 million people with it’s first reported case in Wuhan. The susceptibility to contract the virus was highly dependent on factors such as age sex and associated co-morbidities such as hypertension, obesity and diabetes.
Initiating an overwhelming inflammatory response, COVID-19 had a known potentiality to lead to severe lung injury and multiple organ failure. The therapeutic effects of statins have been highlighted in this study since they hinder the inflammatory pathway thereby putting a halt to the multiplication of the virus.
The research titled “Effect of statin therapy on SARS-CoV-2 infection-related mortality in hospitalized patients” has been put forth by Lluı´s Masana and colleagues in the European heart journal cardiovascular pharmacotherapy. The summary of the article has been given below:
Objective:
To examine the influence of statin therapy at hospital admission for COVID-19 on in-hospital mortality.
Method:
The study had a retrospective observational design. Mortality risk was examined using Genetic Matching Tests. To determine a Cause-specfic Hazard (CSH); a Cox proportional hazards model was employed. Besides these, a Fine and Gray model (FG) was used to inspect the direct impact of statins on risk. Statistical analysis was utilized to assess the data.
Findings:
Pre-Hospitalization statin therapy was greatly linked to lower in-hospital mortality rates in patients with COVID-19.
On an X-ray examination; patients on statin exhibited a less severe pulmonary effect and the oxygen parameters were better.Patients who were on statins had greater comorbidties than patients not on statins.
Limitations:
The causality could not be predicted owing the the retrospective observational design of the study.
All hazard and risk analysis in the Genetic Matching groups were drafted to compare the mortality between the statin and non-statin groups. Other co-variates could not be deduced.
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