Bidirectional relationship between diabetes and pulmonary function: a systematic review and meta-analysis
There has been increasing evidence concluding lungs being a target organ of diabetes-related pathophysiology, and decreased pulmonary function elevates the risk of diabetes after adjusting for metabolic and demographic factors. Rui-Heng Zhang and colleagues conducted research under the title “Bidirectional relationship between diabetes and pulmonary function: a systematic review and meta-analysis” published in Diabetes and Metabolism Journal. The summary of this article is given below
Objective:
To investigate the bidirectional relationship between diabetes and pulmonary function.
Method:
All studies describing the bidirectional relationship were searched on The Cochrane Library, MEDLINE, Embase, and Web of Science databases. Two reviewers independently extracted study characteristics and evaluated the risk of bias.
Finding:
The investigators conclude that there exists a bidirectional relationship between diabetes and pulmonary dysfunction. These findings call for further investigations into whether or not dynamic changes in glycaemic levels prior and shortly after the diagnosis of diabetes are mediating the harmful effects on pulmonary function or vice versa. Additionally, the current evidence supports that the lungs are a target end-organ for diabetes-related pathophysiology. These findings hence encourage medical management in consideration to pulmonary function in patients with diabetes.
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